Drug Interaction Report

Beta-blockers like levobunolol ophthalmic may reduce the effects of epinephrine. If you have been using levobunolol ophthalmic, you may not respond as well to epinephrine when it is given to treat an emergency such as shock or a severe allergic reaction. In addition, the combination may cause severe high blood pressure and reduced heart rate. Your healthcare provider should always be told if you are receiving, or have recently received, beta-blocker therapy. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Both EPINEPHrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.