Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Focalin (dexmethylphenidate)
- phenylbutazone
Interactions between your drugs
phenylbutazone dexmethylphenidate
Applies to: phenylbutazone, Focalin (dexmethylphenidate)
MONITOR: The coadministration with methylphenidate may increase the plasma concentrations of phenylbutazone. According to the manufacturer, human pharmacologic studies have shown that methylphenidate may inhibit the metabolism of phenylbutazone.
MANAGEMENT: Pharmacologic response to phenylbutazone should be monitored more closely whenever methylphenidate (racemic) or dexmethylphenidate (the more pharmacologically active d-enantiomer) is added to or withdrawn from therapy, and the phenylbutazone dosage adjusted as necessary.
References (1)
- (2001) "Product Information. Ritalin (methylphenidate)." Novartis Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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