Drug Interaction Report

Using peanut allergen extract together with desipramine may not be advisable. Immunotherapy with peanut allergen extract can sometimes cause severe, even potentially life-threatening allergic reactions that require emergency treatment with epinephrine, and medications like desipramine can potentiate the body's response to epinephrine and significantly increase its effects on blood pressure and heart rate as well as serious and potentially fatal irregular heart rhythms. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Consumption of alcoholic beverages or products containing alcohol within 2 hours of taking peanut allergen extract may increase the risk and severity of allergic reactions that can sometimes occur during treatment with peanut allergen extract. Do not use alcohol two hours before, or two hours after the dosing time of peanut allergen extract. Potentially life-threatening or fatal reactions may occur. Talk to your doctor if you have any questions or concerns. You should also take peanut allergen extract with a meal, preferably in the evening, and do not take peanut allergen extract within 2 hours of bedtime. Stop using peanut allergen extract, administer epinephrine, and seek immediate medical attention if signs and symptoms of an allergic reaction develop such as trouble breathing, swallowing, or speaking; throat tightness or swelling; dizziness, lightheadedness, or fainting; rapid or weak heartbeat; severe stomach cramps or pain; vomiting or diarrhea; and/or severe flushing or itching. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Ask your doctor before using desipramine together with ethanol (alcohol), this can alter the effects of desipramine and cause increased side effects. Call the doctor if you experience uneven heartbeats, extreme drowsiness, confusion, agitation, vomiting, blurred vision, sweating, muscle stiffness, feeling light-headed, and seizures. You should be warned not to exceed recommended dosages, to avoid alcohol, and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.