Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- cefaclor
- Mylanta Coat & Cool (calcium carbonate / magnesium hydroxide / simethicone)
Interactions between your drugs
cefaclor magnesium hydroxide
Applies to: cefaclor, Mylanta Coat & Cool (calcium carbonate / magnesium hydroxide / simethicone)
ADJUST DOSING INTERVAL: Medications that contain aluminum or magnesium hydroxide may decrease absorption of the cefaclor extended release formulation.
MANAGEMENT: It is recommended that medications that contain aluminum or magnesium hydroxide not be administered within one hour of cefaclor extended release.
References (1)
- (2002) "Product Information. Ceclor (cefaclor)." Lilly, Eli and Company
Drug and food interactions
calcium carbonate food
Applies to: Mylanta Coat & Cool (calcium carbonate / magnesium hydroxide / simethicone)
ADJUST DOSING INTERVAL: Administration with food may increase the absorption of calcium. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption.
MANAGEMENT: Calcium may be administered with food to increase absorption. Consider withholding calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid.
References (6)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Cerner Multum, Inc. "Australian Product Information."
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
- Mangels AR (2014) "Bone nutrients for vegetarians." Am J Clin Nutr, 100, epub
- Davies NT (1979) "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc, 38, p. 121-8
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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