Drug Interaction Report

Nefazodone may increase the blood levels and effects of etrasimod. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. Contact your doctor if your condition changes or you experience increased side effects, such as fever, high temperature or flu-like symptoms, severe headache, confusion, seizures, dizziness, tiredness, lightheadedness, chest pain, shortness of breath, or irregular or abnormal heartbeat, blurriness or shadows in the center of your vision, and nausea, vomiting, abdominal pain, anorexia, or jaundice and/or dark urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Alcohol can increase the nervous system side effects of nefazodone such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with nefazodone. Do not use more than the recommended dose of nefazodone, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Grapefruit juice may increase the blood levels of etrasimod. You should avoid grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with etrasimod unless directed otherwise by your doctor. Talk to your doctor if you have any questions or concerns. Contact your doctor if your condition changes or you experience increased side effects, such as fever, high temperature or flu-like symptoms, severe headache, confusion, seizures, dizziness, tiredness, lightheadedness, chest pain, shortness of breath, or irregular or abnormal heartbeat, blurriness or shadows in the center of your vision, and nausea, vomiting, abdominal pain, anorexia, or jaundice and/or dark urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.