Drug Interaction Report
1 drug interaction and 4 additional warnings found for the following 2 drugs:
- finerenone
- trofinetide
Drug interactions
Moderate drug interactions
Moderate:finerenone trofinetide
Applies to: finerenone, trofinetide
Trofinetide may increase the blood levels and effects of finerenone.
Talk to your doctor if you have any questions or concerns.
You may need more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:Food/Lifestyle finerenone
Applies to: finerenone
Finerenone may be taken with or without food. However, you should avoid grapefruit and grapefruit juice during treatment with this medication. Grapefruit juice may significantly increase the blood levels and effects of finerenone.
This can increase the risk of developing hyperkalemia, or high levels of potassium in the blood, which in severe cases can lead to:
- kidney failure
- muscle paralysis
- irregular heart rhythm
- cardiac arrest
You may be more likely to develop hyperkalemia during treatment with finerenone if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure.
You should also avoid potassium-containing salt substitutes or over-the-counter potassium supplements during treatment with finerenone unless otherwise directed by your doctor.
Seek medical attention if you experience:
- nausea
- vomiting
- weakness
- confusion
- tingling of the hands and feet
- feelings of heaviness in the legs
- a weak pulse
- a slow or irregular heartbeat
These may be symptoms of hyperkalemia.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
3 potential interactionsApplies to: 3 conditions, including Hyperkalemia, Adrenal Insufficiency, and Liver Disease.
Adrenal Insufficiency
Major:finerenone
Finerenone has a major potential interaction with Adrenal Insufficiency.
The use of finerenone is contraindicated in patients with adrenal insufficiency.
Hyperkalemia
Moderate:finerenone
Finerenone has a moderate potential interaction with Hyperkalemia.
Patients with baseline serum potassium over 5.0 mEq/L should not initiate treatment with finerenone. Patients undergoing treatment should have their serum potassium regularly monitored and should have dose adjustments based on their serum potassium concentration.
Liver Disease
Major:finerenone
Finerenone has a major potential interaction with Liver Disease.
The use of finerenone should be avoided in patients with severe liver impairment.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.