Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- methenamine / sodium salicylate
- sulfadiazine
Interactions between your drugs
methenamine sulfADIAZINE
Applies to: methenamine / sodium salicylate, sulfadiazine
CONTRAINDICATED: Some sulfonamides can form an insoluble precipitate with formaldehyde, which is generated from the hydrolysis of methenamine in acidic urine maintained by the presence of hippuric acid.
MANAGEMENT: Methenamine preparations should not be given to patients taking sulfonamides due to the risk of crystalluria. An alkalinizing agent should not be added because this may render methenamine less effective.
References (2)
- (2001) "Product Information. Urised (methenamine)." Polymedica Pharmaceuticals USA Inc
- (2002) "Product Information. Hiprex (methenamine)." Hoechst Marion Roussel
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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