Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- elagolix
- Nuplazid (pimavanserin)
Interactions between your drugs
pimavanserin elagolix
Applies to: Nuplazid (pimavanserin), elagolix
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of pimavanserin, which is primarily metabolized by the isoenzyme. A drug interaction study has shown decreases in pimavanserin Cmax (71%) and AUC (91%) with coadministration of rifampin, a strong CYP450 3A4 inducer. A physiologically based pharmacokinetic simulation with a moderate CYP450 3A4 inducer (efavirenz) predicted Cmax and AUC of pimavanserin will be decreased by approximately 60% and 70%, respectively.
MANAGEMENT: The possibility of diminished therapeutic response to pimavanserin should be considered during coadministration with CYP450 3A4 inducers. The manufacturer recommends coadministration with strong or moderate CYP450 3A4 inducers be avoided.
References (2)
- (2016) "Product Information. Nuplazid (pimavanserin)." Accelis Pharma
- (2025) "Product Information. Nuplazid (pimavanserin)." Acadia Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Eligard
Eligard (leuprolide) reduces levels of testosterone and is used to treat prostate cancer. Includes ...
Provera
Provera is used for abnormal uterine bleeding, amenorrhea, birth control, endometrial cancer ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Depo Provera
Depo-Provera is used as contraception to prevent pregnancy. It is also used to reduce pain cause by ...
Lupron Depot
Lupron Depot is used to treat advanced prostate cancer, endometriosis, uterine fibroids, and ...
Sprintec
Sprintec is used for abnormal uterine bleeding, birth control, endometriosis, gonadotropin ...
Zoladex
Zoladex (goserelin) is used to treat endometriosis and breast cancer in women and prostate cancer ...
Ortho Tri-Cyclen
Ortho Tri-Cyclen (ethinyl estradiol and norgestimate) is used as a contraceptive to prevent ...
Tri-Sprintec
Tri-Sprintec is used for abnormal uterine bleeding, acne, birth control, endometriosis ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.