Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- apalutamide
- Welireg (belzutifan)
Interactions between your drugs
apalutamide belzutifan
Applies to: apalutamide, Welireg (belzutifan)
MONITOR: Coadministration of belzutifan with inducers of CYP450 2C19 may decrease the plasma concentrations and pharmacologic effects of belzutifan. The proposed mechanism is induction of CYP450 2C19, one of the primary pathways for the metabolic clearance of belzutifan. Clinical data are not available.
MANAGEMENT: Caution and clinical monitoring are recommended whenever belzutifan is prescribed in combination with a CYP450 2C19 inducer. Pharmacologic response to belzutifan should be monitored more closely whenever a CYP450 2C19 inducer is added to or withdrawn from therapy.
References (1)
- (2022) "Product Information. Welireg (belzutifan)." Merck Sharp & Dohme (Australia) Pty Ltd
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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