Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- apalutamide
- Zurampic (lesinurad)
Interactions between your drugs
lesinurad apalutamide
Applies to: Zurampic (lesinurad), apalutamide
MONITOR: Coadministration with inducers of CYP450 2C9 may decrease the plasma concentrations of lesinurad. According to the manufacturer, administration of lesinurad with the potent CYP450 inducer rifampin (600 mg daily) decreased lesinurad peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 25% and 40%, respectively, compared to administration of lesinurad alone.
MANAGEMENT: The potential for diminished pharmacologic effects of lesinurad should be considered during coadministration with CYP450 2C9 inducers. Alternative treatments may be required if an interaction is suspected.
References (1)
- (2015) "Product Information. Zurampic (lesinurad)." Astra-Zeneca Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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