Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- meropenem / vaborbactam
- probenecid
Interactions between your drugs
probenecid meropenem
Applies to: probenecid, meropenem / vaborbactam
GENERALLY AVOID: Coadministration with probenecid may increase the plasma concentrations of meropenem. The mechanism involves competitive inhibition of the renal excretion of meropenem via active tubular secretion. In pharmacokinetic studies, probenecid increased meropenem systemic exposure (AUC) by 56% and elimination half-life by 38%.
MANAGEMENT: The use of meropenem in combination with probenecid is not recommended by the manufacturer.
References (2)
- Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ (1989) "The pharmacokinetics of meropenem in volunteers." J Antimicrob Chemother, 24(suppl a, p. 311-20
- (2001) "Product Information. Merrem (meropenem)." Astra-Zeneca Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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