Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- brivaracetam
- Vfend (voriconazole)
Interactions between your drugs
voriconazole brivaracetam
Applies to: Vfend (voriconazole), brivaracetam
According to the manufacturer, brivaracetam is a weak inhibitor of CYP450 2C19 in vitro and is not expected to cause significant inhibition of CYP450 2C19 in humans. No precaution is necessary when brivaracetam is coadministered with CYP450 2C19 substrates.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2016) "Product Information. Briviact (brivaracetam)." UCB Pharma Inc
Drug and food interactions
voriconazole food
Applies to: Vfend (voriconazole)
ADJUST DOSING INTERVAL: Food reduces the oral absorption and bioavailability of voriconazole. According to the product labeling, administration of multiple doses of voriconazole with high-fat meals decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 34% and 24%, respectively, when the drug is administered as a tablet, and by 58% and 37%, respectively, when administered as the oral suspension.
MANAGEMENT: To ensure maximal oral absorption, voriconazole tablets and oral suspension should be taken at least one hour before or after a meal.
References (2)
- (2002) "Product Information. VFEND (voriconazole)." Pfizer U.S. Pharmaceuticals
- Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT (2009) "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm, 66, p. 1438-67
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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