Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Aptiom (eslicarbazepine)
- rosuvastatin
Interactions between your drugs
rosuvastatin eslicarbazepine
Applies to: rosuvastatin, Aptiom (eslicarbazepine)
MONITOR: Coadministration with eslicarbazepine acetate may decrease the plasma concentrations of rosuvastatin. The exact mechanism of interaction has not been established, but may involve eslicarbazepine induction of the metabolism of rosuvastatin via UDP-glucuronyl transferase. In healthy study subjects, rosuvastatin systemic exposure (AUC) decreased by an average of 36% to 39% when coadministered with eslicarbazepine acetate 1200 mg once daily.
MANAGEMENT: The potential for diminished therapeutic effects of rosuvastatin should be considered when prescribed in combination with eslicarbazepine acetate. A dosage increase for rosuvastatin may be required based on efficacy and tolerability.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2013) "Product Information. Aptiom (eslicarbazepine)." Sunovion Pharmaceuticals Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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