Drug Interaction Report

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Thrombotic events have been reported in fitusiran-treated patients, and concurrent use of hormonal contraceptives may increase the risk. Estrogen based hormonal contraceptives are an established risk factor for thrombosis in patients with inherited antithrombin (AT) deficiency.

MANAGEMENT: Concomitant use of fitusiran with estrogen based hormonal contraceptives should generally be avoided. Patients using hormonal contraceptives are advised to use alternative non-hormonal contraception prior to starting treatment with and while receiving fitusiran.

Grapefruit juice may increase the blood levels of certain medications such as dienogest. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with dienogest. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Information for this minor interaction is available on the professional version.