Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Dexilant (dexlansoprazole)
- nelfinavir
Interactions between your drugs
nelfinavir dexlansoprazole
Applies to: nelfinavir, Dexilant (dexlansoprazole)
GENERALLY AVOID: Concurrent use of proton pump inhibitors may decrease the oral bioavailability of nelfinavir and reduce its concentrations in plasma. Nelfinavir solubility may decrease with increasing pH, thus inhibition of gastric acid secretion may interfere with dissolution of the drug. In one study, administration of omeprazole (40 mg once daily) 30 minutes before nelfinavir (1250 mg twice a day) for 4 days reduced the peak plasma concentration, trough plasma concentration, and systemic exposure (AUC) of nelfinavir by a little over one-third.
MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, use of proton pump inhibitors is not recommended in patients treated with nelfinavir.
References (2)
- (2001) "Product Information. Viracept (nelfinavir)." Agouron Pharma Inc
- Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P (2000) "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids, 14, p. 1333-9
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Prilosec
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Prevacid
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Aciphex
Aciphex is used to treat gastroesophageal reflux disease (GERD) and other conditions involving ...
Rabeprazole
Rabeprazole is used for barrett's esophagus, duodenal ulcer, duodenal ulcer prophylaxis, erosive ...
Lansoprazole
Lansoprazole is used to treat stomach and intestinal ulcers, erosive esophagitis and ...
Esomeprazole
Esomeprazole is used for barrett's esophagus, duodenal ulcer prophylaxis, erosive esophagitis ...
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Further information
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