Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- doripenem
- probenecid
Interactions between your drugs
probenecid doripenem
Applies to: probenecid, doripenem
GENERALLY AVOID: Coadministration with probenecid may increase the plasma concentrations of doripenem. The mechanism involves competitive inhibition of the renal excretion of doripenem via active tubular secretion. In pharmacokinetic studies, probenecid increased doripenem systemic exposure (AUC) by 75% and plasma elimination half-life by 53%.
MANAGEMENT: The use of doripenem in combination with probenecid is not recommended by the manufacturer.
References (1)
- (2007) "Product Information. Doribax (doripenem)." Ortho McNeil Pharmaceutical
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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