Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- estradiol topical
- hemin
Interactions between your drugs
estradiol topical hemin
Applies to: estradiol topical, hemin
GENERALLY AVOID: Coadministration with drugs that are capable of increasing the activity of delta-aminolevulinic acid synthetase (e.g., estrogens, barbiturates, steroid metabolites, rifampin) may negate the pharmacologic effect of hemin. In the treatment of porphyria, hemin is thought to limit the rate of porphyrin/heme biosynthesis by inhibiting delta-aminolevulinic acid synthetase, thus any induction of this enzyme would be expected to counteract the therapeutic effect of hemin.
MANAGEMENT: Drugs capable of increasing the activity of delta-aminolevulinic acid synthetase should be avoided during hemin therapy.
References (5)
- (2001) "Product Information. Panhematin (hemin)." Recordati Rare Diseases Inc
- (2023) "Product Information. Normosang (hemin)." Imported (France)
- Pozo OJ, marcos j, Fabregat A, Ventura R, Casals G, Aguilera P, Segura J, To-Figueras J (2014) "Adrenal hormonal imbalance in acute intermittent porphyria patients: results of a case control study" Orphanet Journal of Rare Diseases, 9, p. 54
- anderson ke, Bloomer JR, Bonkovsky HL, Desnick RJ, kushner jp, pierach ca, pimstone nr (2005) Recommendations for the Diagnosis and Treatment of the Acute Porphyrias https://www.acpjournals.org/doi/full/10.7326/0003-4819-142-6-200503150-00010
- Herrick AL, mccoll ke, moore mr, Brodie MJ, Adamson AR, Goldberg A (1989) "Acute intermittent porphyria in two patients on anticonvulsant therapy and with normal erythrocyte porphobilinogen deaminase activity" Br J Clin Pharmacol, 27, 491- 497
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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