Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Nebcin (tobramycin)
- polymyxin b
Interactions between your drugs
tobramycin polymyxin B sulfate
Applies to: Nebcin (tobramycin), polymyxin b
GENERALLY AVOID: The combination of a polypeptide antibiotic and an aminoglycoside may increase the risk of neurotoxicity, respiratory paralysis, and renal dysfunction. The mechanism of this interaction is not known, but may involve additive or synergistic effects.
MANAGEMENT: This combination should be avoided concurrently or sequentially. If coadministration is medically necessary, patients should be closely monitored for development of toxicity, including renal function tests, respiratory function, and vestibular and audiometric tests.
References (7)
- Koch-Weser J, Sidel VW, Federman EB, Kanarek P, Finer DC, Eaton AE (1970) "Adverse effects of sodium colistimethate: manifestations and specific reaction rates during 317 courses of therapy." Ann Intern Med, 72, p. 857-68
- (2002) "Product Information. Amikin (amikacin)." Bristol-Myers Squibb
- (2007) "Product Information. Garamycin (gentamicin)." Schering-Plough Corporation
- (2001) "Product Information. Nebcin (tobramycin)." Lilly, Eli and Company
- Lee C, de Silva AJ (1979) "Interaction of neuromuscular blocking effects of neomycin and polymyxin B." Anesthesiology, 50, p. 218-20
- Lindesmith LA, Baines RD Jr, Bigelow DB, Petty TL (1968) "Reversible respiratory paralysis associated with polymyxin therapy." Ann Intern Med, 68, p. 318-27
- (2018) "Product Information. Arikayce (amikacin liposome)." Insmed Incorporated
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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