Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Clinoril (sulindac)
- dimethyl sulfoxide
Interactions between your drugs
sulindac dimethyl sulfoxide
Applies to: Clinoril (sulindac), dimethyl sulfoxide
GENERALLY AVOID: Dimethyl sulfoxide (DMSO) may reduce serum concentrations of the active metabolite, sulindac sulfide, by inhibiting sulindac reductase. The therapeutic effect of sulindac may be reduced. In addition, concomitant use of these agents has been reported to cause peripheral neuropathy. The mechanism is unknown.
MANAGEMENT: It may be advisable to avoid this drug combination.
References (5)
- Swanson BN, Boppana Vk, Vlasses PH, Rotmensch HH, Ferguson RK (1983) "Dimethyl sulfoxide inhibits bioactivation of sulindac." J Lab Clin Med, 102, p. 95-101
- Reinstein L, Mahon R, Russso GL (1982) "Peripheral neuropathy after concomitant dimethyl sulfoxide use and sulindac therapy." Arch Phys Med Rehabil, 63, p. 581-4
- Swanson BN, Ferguson RK, Raskin NH, Wolf BA (1983) "Peripheral neuropathy after concomitant administration of dimethyl sulfoxide and sulindac." Arthritis Rheum, 26, p. 791-3
- (2001) "Product Information. Clinoril (sulindac)." Merck & Co., Inc
- Cerner Multum, Inc. "Australian Product Information."
Drug and food interactions
sulindac food
Applies to: Clinoril (sulindac)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References (1)
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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