Drug Interaction Report

The following interaction applies only if you are taking sucralfate in the liquid formulation:

Sucralfate oral suspension contains a relatively high carbohydrate content. Patients with diabetes using this medication have occasionally experienced hyperglycemia, or high blood sugar. You may need a dose adjustment of tirzepatide or any other diabetic medications you are receiving during treatment with sucralfate oral suspension. Likewise, if you stop using sucralfate, the dosage(s) of your diabetic medication(s) may need to be readjusted. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

When sucralfate is given with enteral (tube) feedings, the feeding tube may become clogged and/or sucralfate may not work as well. You could interrupt the feeding for 1 hour before and after the sucralfate dose. However, this still may not entirely avoid the interaction and may not always be feasible. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases, this may affect how well and/or how fast those medications work, or it may make no difference. Talk to a healthcare provider if you have any questions or concerns, and contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.