Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- ranitidine bismuth citrate
- Videx EC (didanosine)
Interactions between your drugs
didanosine raNITIdine bismuth citrate
Applies to: Videx EC (didanosine), ranitidine bismuth citrate
Ranitidine may slightly increase the bioavailability of didanosine by increasing gastric pH. This interaction is unlikely to be clinically significant.
References (2)
- Knupp CA, Graziano FM, Dixon RM, Barbhaiya RH (1992) "Pharmacokinetic-interaction study of didanosine and ranitidine in patients seropositive for human immunodeficiency virus." Antimicrob Agents Chemother, 36, p. 2075-9
- (2002) "Product Information. Videx (didanosine)." Bristol-Myers Squibb
Drug and food interactions
didanosine food
Applies to: Videx EC (didanosine)
ADJUST DOSING INTERVAL: Didanosine bioavailability is decreased when administered with food. Loss of efficacy may result.
MANAGEMENT: Didanosine should be administered in the fasting state, at least 30 minutes before or more than 2 hours after eating.
References (1)
- (2002) "Product Information. Videx (didanosine)." Bristol-Myers Squibb
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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