Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Augmentin ES-600 (amoxicillin / clavulanate)
- omadacycline
Interactions between your drugs
amoxicillin omadacycline
Applies to: Augmentin ES-600 (amoxicillin / clavulanate), omadacycline
GENERALLY AVOID: Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by penicillins. Antagonism is more likely when low doses of either agent are administered. Therapeutic failure may result.
MANAGEMENT: This combination should be avoided if possible.
References (6)
- Gunnison JB, Coleman VR, Jawetz E (1950) "Interference of aureomycin and of terramycin with action of penicillin in vitro." Proc Soc Exp Biol Med, 75, p. 549-52
- Lepper MH, Dowling HF (1951) "Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin." Arch Intern Med, 88, p. 489-94
- Jawetz E (1975) "Synergism and antagonism among antimicrobial drugs: a personal perspective." West J Med, 123, p. 87-91
- Olsson RA, Kirby JC, Romansky MJ (1961) "Pneumococcal meningitis in the adult." Ann Intern Med, 55, p. 545-9
- (2001) "Product Information. Declomycin (demeclocycline)." Lederle Laboratories
- (2018) "Product Information. Seysara (sarecycline)." Allergan Inc
Drug and food interactions
omadacycline food
Applies to: omadacycline
ADJUST DOSING INTERVAL: Administration with food, particularly dairy products, may reduce the absorption of omadacycline. The calcium content of these foods may form nonabsorbable chelates with omadacycline.
MANAGEMENT: Omadacycline should be administered at least 2 hours before (4 hours for dairy products) or 4 hours after meals.
References (1)
- (2018) "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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