Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- Phenytoin Sodium, Prompt (phenytoin)
- sodium oxybate
Interactions between your drugs
phenytoin sodium oxybate
Applies to: Phenytoin Sodium, Prompt (phenytoin), sodium oxybate
Using sodium oxybate together with other medications that can affect the central nervous system such as phenytoin may increase side effects like drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, and slow or shallow breathing. Occasionally, severe reactions may result in coma and even death. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Do not drive, operate machinery, or perform other hazardous activities for at least six hours after taking sodium oxybate and until you know how these medications affect you. You should also avoid the use of alcohol during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
sodium oxybate food
Applies to: sodium oxybate
Food may interfere with the absorption of sodium oxybate. You should wait at least 2 hours after eating before you take the first dose. Avoid alcohol during treatment, as it may add to the central nervous system effects of sodium oxybate and increase the risk of serious side effects such as respiratory depression, low blood pressure, fainting, coma, and even death. Do not drive, operate machinery, or perform other hazardous activities for at least six hours after taking sodium oxybate and until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
phenytoin food
Applies to: Phenytoin Sodium, Prompt (phenytoin)
Phenytoin levels may decrease when the suspension is given with enteral feedings. This could lead to a loss of seizure control. You could interrupt the feeding for 2 hours before and after the phenytoin dose. Alternatively, you may give the phenytoin suspension diluted in water and flush the tube with water after administration. These would make it easier for your body to absorb the medication. However, this still may not entirely avoid the interaction and may not always be feasible. You should have your phenytoin levels checked upon starting and stopping of enteral feedings. In addition, using phenytoin together with food may alter the effects of phenytoin. Contact your doctor if you experience worsening of seizure control or symptoms of toxicity, including twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Ask your doctor before making any changes to your therapy.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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