Drug Interaction Report

If you are currently being treated with minocycline or have been treated within the last 3 days, you should talk to your doctor before taking typhoid vaccine, live. Antibiotics like minocycline can reduce the activity of the vaccine. To ensure adequate vaccine response, you should generally not take typhoid vaccine, live until at least 3 days after you complete your antibiotic therapy. If you have already started taking typhoid vaccine, live, it may be advisable to wait at least 3 days after the last dose of vaccine before using minocycline, depending on the urgency of the antibiotic treatment. You should consult with your physician on what is the best course of action for you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Consumer information for this interaction is not currently available.

GENERALLY AVOID: The oral bioavailability of quinolone and tetracycline antibiotics may be reduced by concurrent administration of preparations containing polyvalent cations such as aluminum, calcium, iron, magnesium, and zinc. Therapeutic failure may result. The proposed mechanism is chelation of quinolone and tetracycline antibiotics by di- and trivalent cations, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. Reduced gastrointestinal absorption of the cations should also be considered.

MANAGEMENT: Concomitant administration of oral quinolone and tetracycline antibiotics with preparations containing aluminum, calcium, iron, magnesium, and/or zinc salts should generally be avoided. Otherwise, the times of administration should be staggered by as much as possible to minimize the potential for interaction. Quinolones should typically be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation preparations, depending on the quinolone and formulation. Likewise, tetracyclines and polyvalent cation preparations should typically be administered 2 to 4 hours apart. The prescribing information for the antibiotic should be consulted for more specific dosing recommendations.