Drug Interaction Report

Telaprevir may reduce the blood levels and effects of medroxyPROGESTERone, which may make it less reliable as a form of birth control. You may continue to use medroxyPROGESTERone if desired, but two alternative, non-hormonal methods of birth control should be used during and for two weeks after treatment with telaprevir to avoid unintended pregnancy. This is particularly important because one of the other hepatitis C medications that you must use, ribavirin, is known to cause major birth defects or even death in the unborn child. Examples of non-hormonal methods of birth control include: a male condom with spermicidal jelly OR a female condom with spermicidal jelly--a combination of a male condom and a female condom is not suitable; a diaphragm with spermicidal jelly; a cervical cap with spermicidal jelly; or an intrauterine device (IUD). Talk to your gynecologist or other healthcare professional for help in selecting effective methods of birth control that work best for you. If you take hormone replacement for menopause, you should contact your doctor if you experience increased frequency or worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food significantly increases the absorption of telaprevir. Within 30 minutes before you take each dose of telaprevir, you should eat a meal or snack containing approximately 20 grams of fat. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Examples of some foods that could be taken with telaprevir include: bagel with cream cheese; half cup of nuts; 3 tablespoons of peanut butter; 1 cup of ice cream; 2 ounces of American or cheddar cheese; 2 ounces of potato chips; or half cup of trail mix. Talk to your healthcare provider if you have additional questions about how to take telaprevir.