Drug Interaction Report

Dabrafenib may reduce the blood levels and effects of medroxyPROGESTERone, which may make it less reliable as a form of birth control. Alternative or additional methods of birth control should be used during treatment with dabrafenib to avoid unintended pregnancy. This is particularly important because dabrafenib may cause harm in the unborn child. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. If you take hormone replacement for menopause, you should contact your doctor if you experience increased frequency or worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food may delay and reduce the absorption of dabrafenib, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take dabrafenib at least 1 hour before or 2 hours after a meal.