Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Curretab (medroxyprogesterone)
- etretinate
Interactions between your drugs
medroxyPROGESTERone etretinate
Applies to: Curretab (medroxyprogesterone), etretinate
CONTRAINDICATED: Acitretin interferes with the contraceptive effect of microdosed progestin preparations. The mechanism of interaction has not been described, and it is not known whether the effectiveness of implantable or injectable products are affected.
MANAGEMENT: Because use of acitretin is associated with major birth defects, microdosed 'minipill' progestin preparations are not recommended for women of childbearing potential treated with acitretin. It is not known whether other progestational contraceptives such as implants and injectables offer adequate contraception during acitretin therapy. Simultaneous use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after discontinuing therapy. Input from a gynecologist or similar expert on adequate contraception should be sought as needed.
References (2)
- Berbis P, Bun H, Geiger JM, Rognin C, Durand a, Serradimigni A, Hartmann D, Privat Y (1988) "Acitretin (RO10-1670) and oral contraceptives: interaction study." Arch Dermatol Res, 280, p. 388-9
- (2001) "Product Information. Soriatane (acitretin)." Roche Laboratories
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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