Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- amikacin
- cisplatin
Interactions between your drugs
amikacin CISplatin
Applies to: amikacin, cisplatin
GENERALLY AVOID: Combining cisplatin and aminoglycosides may increase the risk of renal toxicity. Both cisplatin and aminoglycosides have been reported to cause renal magnesium wasting. The exact mechanism of the interaction is unknown.
MANAGEMENT: In patients currently receiving cisplatin therapy, the use of less nephrotoxic antimicrobials is preferable. If cisplatin and an aminoglycoside must be used together, renal function and serum magnesium should be monitored carefully.
References (7)
- Dentino M, Luft FC, Yum MN, et al. (1978) "Long term effect of cis-diamminedichloride platinum (CDDP) on renal function and structure in man." Cancer, 41, p. 1274-81
- Hass A, Anderson L, Lad T (1983) "The influence of aminoglycosides on the nephrotoxicity of cis-diamminedichlorophatinum in cancer patients." J Infect Dis, 147, p. 363
- Patel R, Savage A (1979) "Symptomatic hypomagnesemia associated with gentamicin therapy." Nephron, 23, p. 50-2
- Stewart CF, Christensen ML, Crom WR, Evans WE (1984) "The effect of cisplatin therapy on gentamicin pharmacokinetics." Drug Intell Clin Pharm, 18, p. 512
- Blachley JD, Hill JB (1981) "Renal and electrolyte disturbances associated with cisplatin." Ann Intern Med, 95, p. 628-32
- Christensen ML, Stewart CF, Crom WR (1989) "Evaluation of aminoglycoside disposition in patients previously treated with cisplatin." Ther Drug Monit, 11, p. 631-6
- (2018) "Product Information. Arikayce (amikacin liposome)." Insmed Incorporated
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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