Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Dulcolax Milk of Magnesia (magnesium hydroxide)
- mefenamic acid
Interactions between your drugs
mefenamic acid magnesium hydroxide
Applies to: mefenamic acid, Dulcolax Milk of Magnesia (magnesium hydroxide)
Orally administered magnesium-containing antacids may significantly increase the rate and extent of the absorption of mefenamic acid. No special precautions appear to be necessary.
References (1)
- Neuvonen PJ, Kivisto KT (1988) "Effect of magnesium hydroxide on the absorption of tolfenamic and mefenamic acids." Eur J Clin Pharmacol, 35, p. 495-501
Drug and food interactions
mefenamic acid food
Applies to: mefenamic acid
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References (1)
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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