Drug Interaction Report

Magnesium carbonate may reduce the effectiveness of patiromer in binding potassium. In addition, combining these medications may increase the risk of developing metabolic alkalosis, which is a pH imbalance in the body caused by accumulation of an alkaline substance such as bicarbonate. It may be more likely to occur if you have severe kidney impairment. Symptoms of metabolic alkalosis may include nausea, vomiting, lightheadedness, tremor, muscle twitching, numbness or tingling, prolonged muscle spasms, slowed breathing, irregular heartbeat, confusion, and stupor. Severe cases may lead to seizure and coma. Do not take any over-the-counter antacids or laxatives without consulting with a healthcare professional first. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Patiromer may bind to many different oral medications in the gastrointestinal tract and reduce their absorption into the blood stream. The effectiveness of some oral medications may be decreased when taken with patiromer. To minimize the possibility of interaction, it is recommended that you separate the dosing times of patiromer and any oral medication you take by at least three hours. Talk to your doctor if you are unable to do so or if you have other questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.