Drug Interaction Report

Leuprolide may interfere with blood glucose control and reduce the effectiveness of exenatide and other diabetic medications. Monitor your blood sugar levels closely. You may need a dose adjustment of your diabetic medications during and after treatment with leuprolide. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

You should take exenatide twice a day, at any time within the 60 minutes (1 hour) before your morning and evening meals, or before the two main meals of the day, and at least 6 hours or more apart. You may experience decreased absorption of exenatide in the presence of food or other medications. Your other medications should be administered at least 1 hour before or 2 hours after your exenatide injection.