Drug Interaction Report

GENERALLY AVOID: Because lansoprazole increases gastric pH, it theoretically could decrease absorption of drugs like ampicillin which require an acidic environment.

MANAGEMENT: If lansoprazole therapy is required, consideration should be given to alternative antimicrobial agents.

ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food. The therapeutic effect of the antimicrobial may be reduced.

MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.