Drug Interaction Report

MONITOR CLOSELY: Aminoglycosides possess neuromuscular blocking activity, which may be additive with that of parenteral magnesium, potentially resulting in severe and/or prolonged respiratory depression during concomitant use. Clinical data are limited; however, this interaction has been reported in animal studies. In addition, aminoglycosides may reduce serum magnesium levels.

MANAGEMENT: Close monitoring for increased or prolonged neuromuscular blockade and respiratory depression is recommended during concomitant use, especially in patients with renal impairment and/or with elevated magnesium levels. It may be advisable to avoid administration of aminoglycosides in infants with hypermagnesemia.

ADJUST DOSING INTERVAL: Bowel cleansing products can increase the gastrointestinal transit rate. Oral medications administered within one hour of the start of administration of the bowel cleansing solution may be flushed from the gastrointestinal tract and not properly absorbed.

MANAGEMENT: Patients should be advised that absorption of oral medications may be impaired during bowel cleansing treatment. Oral medications (e.g., anticonvulsants, oral contraceptives, antidiabetic agents, antibiotics) should not be administered during and within one hour of starting bowel cleansing treatment whenever possible. However, if concomitant use cannot be avoided, monitoring for reduced therapeutic effects may be advisable.