Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- halothane
- rifabutin
Interactions between your drugs
halothane rifabutin
Applies to: halothane, rifabutin
GENERALLY AVOID: The hepatotoxic effects of rifampin and isoniazid appear to be increased when these drugs are administered together after halothane anesthesia. Cases of hepatotoxicity and hepatic encephalopathy, one of which was fatal, have been reported. A similar reaction may occur with rifabutin. The mechanism and causality have not been definitely determined since rifampin, isoniazid or halothane alone are potentially hepatotoxic.
MANAGEMENT: Until more information is available, it is best to avoid this combination after halothane anesthesia.
References (4)
- Venkatesan K (1992) "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet, 22, p. 47-65
- Bartelink AK, Lenders JW, van Herwaarden CL, et al. (1983) "Fatal hepatitis after treatment with isoniazid and rifampicin in a patient on anticonvulsant therapy." Tubercle, 64, p. 125-8
- Most JA, Markle GB (1974) "A nearly fatal hepatotoxic reaction to rifampin after halothane anesthesia." Am J Surg, 127, p. 593
- Pessayre D, Bentata M, Degott C, et al. (1977) "Isoniazid-rifampin fulminant hepatitis." Gastroenterology, 72, p. 284-9
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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