Drug Interaction Report

Limited clinical evidence suggests that benzodiazepine effects may have a more rapid onset and be more prolonged when probenecid is used concurrently. The mechanism may be related to interference with hepatic benzodiazepine conjugation. The clinical significance is unknown. Patients should be monitored for prolonged or excessive CNS depression. Benzodiazepine dosage reductions may be necessary.

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.