Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- gentamicin
- vancomycin
Interactions between your drugs
gentamicin vancomycin
Applies to: gentamicin, vancomycin
MONITOR: When administered concomitantly, glycopeptide antibiotics and parenteral aminoglycosides or oral neomycin may have additive nephrotoxic or neurotoxic effects.
MANAGEMENT: If these drugs must be used together, renal function and serum drug concentrations should be monitored.
References (6)
- Odio C, McCracken GH, Nelson JD (1984) "Nephrotoxicity associated with vancomycin-aminoglycoside therapy in four children." J Pediatr, 105, p. 491-2
- Dean RP, Wagner DJ, Tolpin MD (1985) "Vancomycin/aminoglycoside nephrotoxicity." J Pediatr, 106, p. 861-2
- Sorrell TC, Collignon PJ (1985) "A prospective study of adverse reactions associated with vancomycin therapy." J Antimicrob Chemother, 16, p. 235-41
- Downs NJ, Neihart RE, Dolezal JM, Hodges GR (1989) "Mild nephrotoxicity associated with vancomycin use." Arch Intern Med, 149, p. 1777-81
- Pauly DJ, Musa DM, Lestico MR, Lindstrom MJ, Hetsko CM (1990) "Risk of nephrotoxicity with combination vancomycin-aminoglycoside antibiotic therapy." Pharmacotherapy, 10, p. 378-82
- Farber BF, Moellering RC Jr (1983) "Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981." Antimicrob Agents Chemother, 23, p. 138-41
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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