Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- fosphenytoin
- tubocurarine
Interactions between your drugs
tubocurarine fosphenytoin
Applies to: tubocurarine, fosphenytoin
MONITOR: Case reports have suggested that long-term phenytoin administration may decrease the effectiveness of neuromuscular blocker and increase the dosage requirements. One of the proposed mechanisms is hepatic enzyme induction by phenytoin. Conversely, acute phenytoin administration may increase neuromuscular blocking effects by an unknown mechanism. Other hydantoins may interact with other non-depolarizing neuromuscular blockers in a similar fashion.
MANAGEMENT: Close observation for evidence of altered effects of neuromuscular blocking agents is indicated if these drugs must be used together.
References (2)
- Plotkin CN, Ornstein E (1986) "Resistance to pancuronium: adult respiratory distress syndrome or phenytoin." Anesth Analg, 65, p. 819-27
- Liberman BA, Norman P, Hardy BG (1988) "Pancuronium-phenytoin interaction: a case of decreased duration of neuromuscular blockade." Int J Clin Pharmacol Ther Toxicol, 26, p. 371-4
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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