Drug Interaction Report

Before using estropipate topical, tell your doctor if you also use liotrix. You may need dose adjustments or extra monitoring to safely take both medications together. If you are already using estropipate topical and liotrix, your thyroid levels may need to be measured if your dose of estropipate topical is changed or stopped. You should notify your doctor if you have symptoms of low thyroid hormone levels such as tiredness, feeling cold, constipation, unexplained weight gain, depression, joint or muscle pain, thinning hair or hair loss, dry skin, hoarseness, and abnormal menstrual periods. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

The timing of meals relative to your oral liotrix dose can affect the absorption of the medication. Therefore, liotrix should be taken on a consistent schedule with regard to time of day and relation to meals to avoid large fluctuations in blood levels, which may alter its effects. In addition, absorption of liotrix may be decreased and/or delayed by foods such as soybean flour, cotton seed meal, walnuts, dietary fiber, calcium, calcium fortified juices and grapefruit or grapefruit juice. These foods should be avoided within several hours of dosing if possible. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Using multivitamin with minerals together with liotrix may decrease the effects of liotrix. You should separate the administration of liotrix and multivitamin with minerals by at least 4 hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.