Xphozah and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Xphozah (tenapanor).
Tenapanor Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Administration of tenapanor immediately before a meal may enhance its effectiveness. In clinical trials, administration of tenapanor 5 to 10 minutes before a meal increased the 24-hour stool sodium excretion compared to taking tenapanor in the fed or fasting state. The resulting higher levels of sodium in the intestine and colon cause an increase in water secretion into the intestinal lumen, which accelerates intestinal transit time and results in a softer stool consistency.
MANAGEMENT: The manufacturer recommends administering tenapanor immediately prior to breakfast or the first meal of the day and immediately prior to dinner.
References (1)
- (2019) "Product Information. Ibsrela (tenapanor)." Ardelyx, Inc
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Xphozah disease interactions
There is 1 disease interaction with Xphozah (tenapanor) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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