Seldane-D (pseudoephedrine / terfenadine) and Alcohol / Food Interactions
There is 1 alcohol/food/lifestyle interaction with Seldane-D (pseudoephedrine / terfenadine):
terfenadine ↔ food
Major Food Interaction
Consumer information for this interaction is not currently available.
CONTRAINDICATED: The consumption of grapefruit juice has been associated with significantly increased plasma concentrations of terfenadine. The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall induced by certain compounds present in grapefruits. Terfenadine in high serum levels has been associated with prolongation of the QT interval and development of torsade de pointes, a potentially fatal ventricular arrhythmia.
MANAGEMENT: Due to the risk of cardiotoxicity, patients receiving the drug should be advised to avoid consumption of grapefruit products. Loratadine, cetirizine, and fexofenadine may be safer alternatives in patients who may have trouble adhering to the dietary restriction.
- Zimmermann M, Duruz H, Guinand O, et al "Torsades de Pointes after treatment with terfenadine and ketoconazole." Eur Heart J 13 (1992): 1002-3
- Honig PK, Wortham DC, Zamani K, et al "Terfenadine-ketoconazole interaction: pharmacokinetic and electrocardiographic consequences." JAMA 269 (1993): 1513-8
- Pohjola-Sintonen S, Viitasalo M, Toivonene L, Neuvonen P "Torsades de pointes after terfenadine-itraconazole interaction." BMJ 306 (1993): 186
Seldane-D (pseudoephedrine / terfenadine) drug Interactions
There are 533 drug interactions with Seldane-D (pseudoephedrine / terfenadine)
Seldane-D (pseudoephedrine / terfenadine) disease Interactions
There are 6 disease interactions with Seldane-D (pseudoephedrine / terfenadine) which include:
Drug Interaction Classification
Do not stop taking any medications without consulting your healthcare provider.