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Piperacillin / tazobactam and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with piperacillin / tazobactam:


High Blood Pressure (Hypertension)

Moderate Potential Hazard, High plausibility

piperacillin - sodium/potassium

Parenteral piperacillin sodium contains approximately 43 mg (1.85 mEq) of sodium per each gram of piperacillin activity. The combination, piperacillin-tazobactam, contains approximately 54 mg (2.35 mEq) of sodium per gram of piperacillin, or 108 mg (4.7 mEq) per 2.25 gram of total drug. The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention. In addition, hypokalemia has been reported rarely during therapy with piperacillin and other extended-spectrum penicillin antibiotics, which may be particularly important to bear in mind when treating patients with low potassium reserves or fluid and electrolyte imbalance. Clinical monitoring of electrolytes is recommended if these agents are used for prolonged periods.


  1. "Product Information. Zosyn (piperacillin-tazobactam)." Lederle Laboratories, Wayne, NJ.
  2. Nanji AA, Lindsay J "Ticarcillin associated hypokalemia." Clin Biochem 15 (1982): 118-9
  3. "Product Information. Ticar (ticarcillin)." SmithKline Beecham, Philadelphia, PA.

Piperacillin / tazobactam drug interactions

There are 86 drug interactions with piperacillin / tazobactam

Piperacillin / tazobactam disease interactions

There are 7 disease interactions with piperacillin / tazobactam which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.