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Actos and Alcohol/Food Interactions

There are 3 alcohol/food/lifestyle interactions with Actos (pioglitazone).


Pioglitazone Food

Moderate Food Interaction

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, it may be best to limit alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with your normal meal plan. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Pioglitazone High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

thiazolidinediones - edema

Thiazolidinediones can cause dose-related edema. Therapy with thiazolidinediones should be administered cautiously in patients at risk for congestive heart failure as well as those with fluid overload or other conditions that may be adversely affected by excess fluid such as hypertension. Patients should be monitored for signs and symptoms of heart failure such as dyspnea, swelling of legs or ankles, and weight gain.


  1. (2001) "Product Information. Rezulin (troglitazone)." Parke-Davis
  2. (2001) "Product Information. Avandia (rosiglitazone)." SmithKline Beecham
  3. (2001) "Product Information. Actos (pioglitazone)." Takeda Pharmaceuticals America
  4. Thomas ML, Lloyd SJ (2001) "Pulmonary edema associated with rosiglitazone and troglitazone." Ann Pharmacother, 35, p. 123-4
View all 4 references

Pioglitazone Obesity

Moderate Potential Hazard, Moderate plausibility

thiazolidinediones - weight gain

Thiazolidinediones can cause dose-related weight gain, which may be undesirable in obese patients attempting to lose weight. The mechanism of weight gain is unclear but probably involves a combination of fluid retention and fat accumulation. In postmarketing experience with rosiglitazone, there have been reports of unusually rapid increases in weight, greater than those generally observed in clinical trials. Patients who experience such increases should be assessed for fluid retention and volume-related events such as excessive edema and congestive heart failure.


  1. (2001) "Product Information. Avandia (rosiglitazone)." SmithKline Beecham
  2. (2001) "Product Information. Actos (pioglitazone)." Takeda Pharmaceuticals America

Actos drug interactions

There are 334 drug interactions with Actos (pioglitazone).

Actos disease interactions

There are 9 disease interactions with Actos (pioglitazone) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.