Ixazomib and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with ixazomib.
Ixazomib Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of ixazomib. A food effect study found that administration of a single 4 mg dose of ixazomib with a high-fat meal decreased ixazomib peak plasma concentration (Cmax) by 69% and systemic exposure (AUC) by 28%.
MANAGEMENT: Ixazomib should be taken at least one hour before or two hours after eating. On days when both ixazomib and dexamethasone are administered, advise patients to separate dosing times, since dexamethasone should be taken with food while ixazomib should be taken on an empty stomach.
References (1)
- (2015) "Product Information. Ninlaro (ixazomib)." Takeda Pharmaceuticals America
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Ixazomib drug interactions
There are 362 drug interactions with ixazomib.
Ixazomib disease interactions
There are 5 disease interactions with ixazomib which include:
- gastrointestinal toxicities
- hepatic impairment
- peripheral neuropathy
- renal impairment
- thrombocytopenia
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- Reviews (3)
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- During pregnancy
- Drug class: proteasome inhibitors
- Breastfeeding
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
