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Ixazomib Disease Interactions

There are 5 disease interactions with ixazomib:

Moderate

Ixazomib (applies to ixazomib) gastrointestinal toxicities

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diarrhea, Vomiting, Constipation

Ixazomib may cause diarrhea, constipation, nausea, and vomiting. Care should be taken when using this agent in patients experiencing gastrointestinal complications. It is recommended to adjust the dose of this agent as per the manufacturer dosing instructions for Grade 3 or 4 symptoms. Evaluate for underlying causes and provide supportive care as necessary.

Moderate

Ixazomib (applies to ixazomib) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Pharmacokinetic studies of ixazomib in patients with moderate to severe hepatic impairment, showed an increase AUC when compared to patients with normal hepatic function. The pharmacokinetic of ixazomib was similar in patients with normal hepatic function and in patients with mild hepatic impairment. It is recommended to reduce the starting dose in patients with moderate to severe hepatic impairment. Caution should be exercised when ixazomib is administered to patients with moderate to severe hepatic function and monitoring of liver function tests is recommended as appropriate.

Moderate

Ixazomib (applies to ixazomib) peripheral neuropathy

Moderate Potential Hazard, Moderate plausibility.

Peripheral neuropathy has been reported with the use of ixazomib. Patients should be monitored for symptoms of neuropathy and if they are experiencing new or worsening peripheral neuropathy, it is recommended to withhold therapy and modify the dose as per manufacturer instructions.

Moderate

Ixazomib (applies to ixazomib) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Population PK analysis in patients with severe renal impairment or ESRD requiring dialysis showed an increase AUC when compared to patients with normal renal function. The pharmacokinetic of ixazomib was similar in patients with normal renal function and in patients with mild or moderate renal impairment. It is recommended to reduce the starting dose in patients with severe renal impairment or ESRD requiring dialysis. Caution should be exercised when ixazomib is administered to patients with severe renal impairment. Ixazomib is not dialyzable and therefore can be administered without regard to the timing of dialysis

Moderate

Ixazomib (applies to ixazomib) thrombocytopenia

Moderate Potential Hazard, Moderate plausibility.

Thrombocytopenia has been reported with the use of ixazomib. It is recommended to monitor platelet counts regularly during treatment and to considered withholding therapy or dosage modifications and platelet transfusions as per manufacturer recommendations and clinical guidelines.

Ixazomib drug interactions

There are 261 drug interactions with ixazomib

Ixazomib alcohol/food interactions

There is 1 alcohol/food interaction with ixazomib

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.