Uro-458 (hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate) and Alcohol/Food Interactions
There are 4 alcohol/food/lifestyle interactions with Uro-458 (hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate) which include:
sodium biphosphate Alcohol (Ethanol)
Major Drug Interaction
The following interaction applies only to products containing sodium biphosphate that are used for bowel cleansing. It does not apply to products containing sodium biphosphate that are used for other, non-laxative related purposes. Bowel cleansing with sodium biphosphate can cause kidney failure, in some cases up to several months after the procedure. Although it rarely occurs, the risk is increased in individuals receiving treatment with phenyl salicylate, especially if they are also elderly or frail. You may need a dose adjustment or special tests to safely use both medications. Combining these medications may also increase the risk of dehydration and electrolyte abnormalities. In severe cases, dehydration and electrolyte abnormalities can lead to irregular heart rhythm, seizures, and kidney problems. You should use sodium biphosphate exactly as prescribed by your doctor, and drink plenty of clear fluids before, during, and after the cleansing process to keep yourself hydrated. Your doctor may also recommend an electrolyte rehydration solution that you can use. Talk to your doctor if you have any concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
hyoscyamine Alcohol (Ethanol)
Moderate Drug Interaction
Ask your doctor before using hyoscyamine together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking hyoscyamine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
sodium biphosphate food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Bowel cleansing products can increase the gastrointestinal transit rate. Oral medications administered within one hour of the start of administration of the bowel cleansing solution may be flushed from the gastrointestinal tract and not properly absorbed.
MANAGEMENT: Patients should be advised that absorption of oral medications may be impaired during bowel cleansing treatment. Oral medications (e.g., anticonvulsants, oral contraceptives, antidiabetic agents, antibiotics) should not be administered during and within one hour of starting bowel cleansing treatment whenever possible. However, if concomitant use cannot be avoided, monitoring for reduced therapeutic effects may be advisable.
- "Product Information. Golytely (polyethylene glycol electrolyte solution)." Braintree, Braintree, MA.
- "Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate)." Ferring Pharmaceuticals Inc, Tarrytown, NY.
High Blood Pressure (Hypertension)
Minor Potential Hazard, Low plausibility
anticholinergics - hypertension
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
- "Product Information. Marezine (cyclizine)." Glaxo Wellcome, Research Triangle Park, NC.
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.
- Valentin N, Staffeldt H, Kyst A "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand 28 (1984): 621-4
- "Product Information. Atropine Sulfate Injection, USP (atropine)." ESI Lederle Generics, Philadelphia, PA.
- "Product Information. Antivert (meclizine)." Roerig Division, New York, NY.
- "Product Information. Cogentin (benztropine)." Merck & Co, Inc, West Point, PA.
- "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories, Wayne, NJ.
Uro-458 (hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate) drug interactions
There are 723 drug interactions with Uro-458 (hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate)
Uro-458 (hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate) disease interactions
There are 37 disease interactions with Uro-458 (hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate) which include:
- autonomic neuropathy
- GI obstruction
- obstructive uropathy
- reactive airway diseases
- myasthenia gravis
- infectious diarrhea
- inflammatory bowel disease
- intestinal obstruction disorders
- liver disease
- methemoglobinemia in G-6-PD
- phosphate imbalance
- GI toxicity
- renal dysfunction
- Reye's syndrome
- electrolyte imbalance
- cardiac disease
- coronary artery disease
- gastric ulcer
- gastroesophageal reflux
- ulcerative colitis
- liver disease
- renal failure
- renal dysfunction
- G-6-PD deficiency
More about Uro-458 (hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate)
- Side Effects
- Dosage Information
- Imprints, Shape & Color Data
- Drug Interactions
- Drug class: urinary antispasmodics
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.