Fosphenytoin and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with fosphenytoin.
Alcohol (Ethanol) Fosphenytoin
Moderate Drug Interaction
MONITOR: Acute consumption of alcohol may increase plasma phenytoin levels. Chronic consumption of alcohol may decrease plasma phenytoin levels. The mechanism of this interaction is related to induction of phenytoin metabolism by ethanol during chronic administration. Other hydantoin derivatives may be similarly affected by ethanol.
MANAGEMENT: Patients receiving phenytoin therapy should be warned about the interaction between phenytoin and ethanol and they should be advised to notify their physician if they experience worsening of seizure control or symptoms of toxicity, including drowsiness, visual disturbances, change in mental status, nausea, or ataxia.
References (5)
- Sandor P, Sellers EM, Dumbrell M, Khouw V (1981) "Effect of short- and long-term alcohol use on phenytoin kinetics in chronic alcoholics." Clin Pharmacol Ther, 30, p. 390-7
- Sellers EM, Holloway MR (1978) "Drug kinetics and alcohol ingestion." Clin Pharmacokinet, 3, p. 440-52
- (2001) "Product Information. Dilantin (phenytoin)." Parke-Davis
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
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Fosphenytoin drug interactions
There are 760 drug interactions with fosphenytoin.
Fosphenytoin disease interactions
There are 12 disease interactions with fosphenytoin which include:
- blood dyscrasias
- liver disease
- porphyria
- renal dysfunction
- cardiotoxicity
- suicidal tendency
- renal dysfunction
- hyperglycemia
- megaloblastic anemia
- osteomalacia
- alcoholism
- thyroid function tests
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- Drug class: hydantoin anticonvulsants
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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