Tikosyn and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Tikosyn (dofetilide).
Dofetilide Food
Minor Food Interaction
In vitro data suggest that grapefruit juice may inhibit the CYP450 3A4 first-pass metabolism of dofetilide. Decreased first-pass metabolism may increase dofetilide concentrations and increase the risk of QT interval prolongation and arrhythmias. The clinical significance is unknown, since dofetilide has a high oral bioavailability and a low affinity for CYP450 3A4. The manufacturer recommends caution.
References (1)
- (2001) "Product Information. Tikosyn (dofetilide)." Pfizer U.S. Pharmaceuticals
Switch to consumer interaction data
Tikosyn drug interactions
There are 423 drug interactions with Tikosyn (dofetilide).
Tikosyn disease interactions
There are 5 disease interactions with Tikosyn (dofetilide) which include:
Report options
More about Tikosyn (dofetilide)
- Tikosyn consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (62)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Generic availability
- Drug class: group III antiarrhythmics
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Pacerone
Pacerone is used for arrhythmia, supraventricular tachycardia, ventricular fibrillation ...
Cordarone
Cordarone is used for arrhythmia, supraventricular tachycardia, ventricular fibrillation ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Mexiletine
Mexiletine is used for arrhythmia, diabetic peripheral neuropathy, myotonia congenita, ventricular ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
