Conjugated estrogens topical and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with conjugated estrogens topical.
Conjugated Estrogens Topical High Blood Pressure (Hypertension)
Major Potential Hazard, High plausibility
estrogens - hypertension
The risk of myocardial infarction and strokes, including those associated with oral contraceptive use and some estrogen use, is increased in patients with hypertension. Moreover, estrogens (and progestogens) may elevate blood pressure and worsen the hypertension, thus compounding the risk. Clinically significant blood pressure increases have been reported during estrogen therapy, particularly in patients receiving high dosages or treated with oral contraceptive combinations having high progestational activity. These effects also increase with duration of therapy and patient age. Therapy with estrogens should be administered cautiously in patients with preexisting hypertension. Some estrogen-based therapies, such as combined hormonal contraceptives, may be contraindicated in patients with uncontrolled hypertension or hypertension with vascular disease. Patients should be monitored for changes in cardiovascular status, and their antihypertensive regimen adjusted or estrogen therapy withdrawn as necessary. In patients requiring contraception, alternative methods should be considered for those who are hypertensive, over age 35, and smoke.
References (26)
- "Product Information. Ortho-Novum 10/11 (ethinyl estradiol-norethindrone)." Ortho McNeil Pharmaceutical
- (2001) "Product Information. Ortho-Cept (desogestrel-ethinyl estradiol)." Ortho McNeil Pharmaceutical
- "Product Information. Demulen 1/50 (ethinyl estradiol-ethynodiol)." Searle
- (2001) "Product Information. Triphasil (ethinyl estradiol-levonorgestrel)." Wyeth-Ayerst Laboratories
- (2001) "Product Information. Ortho-Cyclen (ethinyl estradiol-norgestimate)." Ortho McNeil Pharmaceutical
- (2001) "Product Information. Lo/Ovral (ethinyl estradiol-norgestrel)." Wyeth-Ayerst Laboratories
- "Product Information. Ortho-Novum 1/50 (mestranol-norethindrone)." Ortho McNeil Pharmaceutical
- (2001) "Product Information. Ortho-Est (estropipate)." Ortho McNeil Pharmaceutical
- (2001) "Product Information. Ogen (estropipate topical)." Pharmacia and Upjohn
- "Product Information. Estinyl (ethinyl estradiol)." Schering Corporation
- (2001) "Product Information. Estratab (esterified estrogens)." Solvay Pharmaceuticals Inc
- (2021) "Product Information. Nextstellis (drospirenone-estetrol)." Mayne Pharma
- (2024) "Product Information. Estradiol (estradiol)." Alexso Inc
- (2024) "Product Information. EstroGel Pump (estradiol)." Ascend Therapeutics
- (2023) "Product Information. Elestrin Pump (estradiol)." Meda Pharmaceuticals
- (2023) "Product Information. Femring (estradiol)." Millicent Pharma
- (2024) "Product Information. Minivelle (estradiol)." Noven Pharmaceuticals, Inc.
- (2024) "Product Information. Dotti (estradiol)." Amneal Pharmaceuticals LLC
- (2024) "Product Information. Lyllana (estradiol)." Amneal Pharmaceuticals
- (2023) "Product Information. Alora (estradiol)." Allergan Inc
- (2023) "Product Information. Menostar (estradiol)." Berlex Laboratories
- (2023) "Product Information. Divigel (estradiol)." Vertical Pharmaceuticals Inc
- (2024) "Product Information. Evamist (estradiol)." Padagis
- (2024) "Product Information. Depo-Estradiol (estradiol)." Pfizer U.S. Pharmaceuticals Group
- (2024) "Product Information. Delestrogen (estradiol)." Bristol-Myers Squibb
- (2025) "Product Information. Premarin (conjugated estrogens)." Wyeth Laboratories
Conjugated Estrogens Topical High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
estrogens - hyperlipidemia
Estrogens may cause adverse lipid changes. Use of estrogens has been associated with elevations in triglyceride levels, particularly in women with pre-existing hypertriglyceridemia. Discontinue therapy if elevated triglycerides lead to pancreatitis. Manage hypercholesterolemia appropriately as indicated.
References (28)
- "Product Information. Ortho-Novum 10/11 (ethinyl estradiol-norethindrone)." Ortho McNeil Pharmaceutical
- (2001) "Product Information. Ortho-Cept (desogestrel-ethinyl estradiol)." Ortho McNeil Pharmaceutical
- "Product Information. Demulen 1/50 (ethinyl estradiol-ethynodiol)." Searle
- (2001) "Product Information. Triphasil (ethinyl estradiol-levonorgestrel)." Wyeth-Ayerst Laboratories
- (2001) "Product Information. Ortho-Cyclen (ethinyl estradiol-norgestimate)." Ortho McNeil Pharmaceutical
- (2001) "Product Information. Lo/Ovral (ethinyl estradiol-norgestrel)." Wyeth-Ayerst Laboratories
- "Product Information. Ortho-Novum 1/50 (mestranol-norethindrone)." Ortho McNeil Pharmaceutical
- (2001) "Product Information. Ogen (estropipate topical)." Pharmacia and Upjohn
- "Product Information. Estinyl (ethinyl estradiol)." Schering Corporation
- (2001) "Product Information. Estratab (esterified estrogens)." Solvay Pharmaceuticals Inc
- (2017) "Product Information. Premarin Vaginal (conjugated estrogens topical)." Wyeth Laboratories
- (2019) "Product Information. Menest (esterified estrogens)." Pfizer U.S. Pharmaceuticals Group
- (2021) "Product Information. Nextstellis (drospirenone-estetrol)." Mayne Pharma
- (2024) "Product Information. Estradiol (estradiol)." Alexso Inc
- (2024) "Product Information. EstroGel Pump (estradiol)." Ascend Therapeutics
- (2023) "Product Information. Elestrin Pump (estradiol)." Meda Pharmaceuticals
- (2023) "Product Information. Femring (estradiol)." Millicent Pharma
- (2024) "Product Information. Minivelle (estradiol)." Noven Pharmaceuticals, Inc.
- (2024) "Product Information. Dotti (estradiol)." Amneal Pharmaceuticals LLC
- (2024) "Product Information. Lyllana (estradiol)." Amneal Pharmaceuticals
- (2023) "Product Information. Alora (estradiol)." Allergan Inc
- (2023) "Product Information. Menostar (estradiol)." Berlex Laboratories
- (2023) "Product Information. Divigel (estradiol)." Vertical Pharmaceuticals Inc
- (2024) "Product Information. Evamist (estradiol)." Padagis
- (2024) "Product Information. Depo-Estradiol (estradiol)." Pfizer U.S. Pharmaceuticals Group
- (2024) "Product Information. Delestrogen (estradiol)." Bristol-Myers Squibb
- (2024) "Product Information. Ogen 2.5 (estropipate)." Pfizer U.S. Pharmaceuticals Group
- (2025) "Product Information. Premarin (conjugated estrogens)." Wyeth Laboratories
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Conjugated estrogens topical drug interactions
There are 214 drug interactions with conjugated estrogens topical.
Conjugated estrogens topical disease interactions
There are 14 disease interactions with conjugated estrogens topical which include:
- abnormal vaginal bleeding
- carcinomas (estrogenic)
- hypercalcemia in breast cancer
- hypertension
- thromboembolism/cardiovascular
- hepatic neoplasms
- angioedema
- gallbladder disease
- hyperlipidemia
- hypoparathyroidism
- liver disease
- fluid retention
- glucose intolerance
- thyroid function tests
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- Reviews (22)
- Side effects
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- During pregnancy
- Drug class: estrogens
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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