Chlordinium (chlordiazepoxide / clidinium) and Alcohol / Food Interactions
There are 3 alcohol/food/lifestyle interactions with Chlordinium (chlordiazepoxide / clidinium) which include:
chlordiazePOXIDE ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc, Teaneck, NJ.
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc, Rockville, MD.
Moderate Potential Hazard, Moderate plausibility
benzodiazepines - obesity
The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.
- "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Librium (chlordiazepoxide)." Roche Laboratories, Nutley, NJ.
- "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Halcion (triazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. Klonopin (clonazepam)." Roche Laboratories, Nutley, NJ.
- "Product Information. ProSom (estazolam)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Valium (diazepam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Doral (quazepam)." Wallace Laboratories, Cranbury, NJ.
- "Product Information. Versed (midazolam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Dalmane (flurazepam)." Roche Laboratories, Nutley, NJ.
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
High Blood Pressure (Hypertension)
Minor Potential Hazard, Moderate plausibility
anticholinergics - hypertension
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
- "Product Information. Marezine (cyclizine)." Glaxo Wellcome, Research Triangle Park, NC.
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.
- "Product Information. Cogentin (benztropine)." Merck & Co, Inc, West Point, PA.
- "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories, Wayne, NJ.
- Valentin N, Staffeldt H, Kyst A "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand 28 (1984): 621-4
- "Product Information. Antivert (meclizine)." Roerig Division, New York, NY.
- "Product Information. Atropine Sulfate Injection, USP (atropine)." ESI Lederle Generics, Philadelphia, PA.
Chlordinium (chlordiazepoxide / clidinium) drug Interactions
There are 1016 drug interactions with Chlordinium (chlordiazepoxide / clidinium)
Chlordinium (chlordiazepoxide / clidinium) disease Interactions
There are 21 disease interactions with Chlordinium (chlordiazepoxide / clidinium) which include:
- Autonomic Neuropathy
- Gi Obstruction
- Obstructive Uropathy
- Tardive Dyskinesia
- Infectious Diarrhea
- Acute Alcohol Intoxication
- Closed-Angle Glaucoma
- Drug Dependence
- Renal/Liver Disease
- Respiratory Depression
- Prolonged Hypotension
- Paradoxical Reactions
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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