Librium (chlordiazepoxide) and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Librium (chlordiazepoxide) which include:
Moderate Food Interaction
Alcohol can increase the nervous system side effects of chlordiazePOXIDE such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlordiazePOXIDE. Do not use more than the recommended dose of chlordiazePOXIDE, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate Potential Hazard, Moderate plausibility
benzodiazepines - obesity
The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.
- "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Halcion (triazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Librium (chlordiazepoxide)." Roche Laboratories, Nutley, NJ.
- "Product Information. Klonopin (clonazepam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Valium (diazepam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Versed (midazolam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Doral (quazepam)." Wallace Laboratories, Cranbury, NJ.
- "Product Information. Dalmane (flurazepam)." Roche Laboratories, Nutley, NJ.
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
- "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. ProSom (estazolam)." Abbott Pharmaceutical, Abbott Park, IL.
Librium (chlordiazepoxide) drug interactions
There are 412 drug interactions with Librium (chlordiazepoxide)
Librium (chlordiazepoxide) disease interactions
There are 11 disease interactions with Librium (chlordiazepoxide) which include:
- acute alcohol intoxication
- closed-angle glaucoma
- drug dependence
- renal/liver disease
- respiratory depression
- prolonged hypotension
- paradoxical reactions
More about Librium (chlordiazepoxide)
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- During Pregnancy or Breastfeeding
- Dosage Information
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- 160 Reviews
- Drug class: benzodiazepines
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|